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What is etonogestrel?

Etonogestrel (Nexplanon®) is a contraceptive implant placed under the skin of the upper arm. It can prevent pregnancy for up to 3 years by stopping ovulation. When positioned correctly, it is over 99% effective.

Care at home

  • Remove the outer bandage after 24 hours; keep the smaller bandage clean and dry for 3–5 days.
  • Report abdominal pain, suspected pregnancy, or implant issues to your doctor immediately.

Possible side effects

  • Temporary pain, irritation, or bruising at the insertion site
  • Changes in menstrual bleeding (shorter, longer, spotting, or no bleeding)
  • Weight gain
  • Headache
  • Acne
  • Mood swings or depression
  • Symptoms of an allergic reaction include rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck
  • Not all patients will experience these side effects. Report any symptoms to the care team.

Tips for patients and families

  • Discuss all questions with your doctor or pharmacist.
  • Nexplanon is inserted in the doctor's office under local anesthesia; a pressure bandage is worn for 24 hours followed by a small bandage for 3–5 days.
  • Confirm placement by feeling the implant with your doctor after insertion.
  • The procedure may be scheduled during the first days of your period; a pregnancy test may be done before placement.
  • Plan for removal at 3 years or sooner if pregnancy is desired or side effects occur; removal is similar to insertion.
  • Call your doctor if you cannot feel the implant, think it is bent or broken, or suspect pregnancy.
  • Tell your doctor about all medicines and OTC products, as some can reduce Nexplanon's effectiveness.
  • Use backup contraception if the implant cannot be located and until confirmed in place.
  • For pregnancy planning, fertility may return within 1–2 weeks after removal.
  • Nexplanon does not protect against HIV or STDs; use condoms for protection.