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What is Factor VIII (Human) and von Willebrand Factor?

Human Factor VIII with von Willebrand factor replenishes clotting factors to manage bleeding disorders. It is supplied as a powder to be mixed with sterile water and given by IV.

Possible side effects

  • Allergic reactions (itching, hives, swelling, chest tightness, trouble breathing)
  • Fever or chills
  • Lightheadedness or fainting
  • Yellowing skin or eyes
  • Drowsiness or fatigue
  • Headache
  • Nausea or mild stomach pain
  • Pain, itching, swelling, burning, or lumps at injection site
  • Symptoms of allergic reaction include rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in throat, swelling of face or neck
  • Not all patients will experience these side effects. Report any symptoms to the care team.

Tips for patients and families

  • Discuss all questions with your doctor or pharmacist.
  • Store in the refrigerator or at room temperature for up to 6 months (record the date if kept at room temperature); do not freeze.
  • Do not use past the expiration date.
  • Home infusion may be taught; ensure you understand all instructions before self-administration.
  • Have another trained person available if possible; contact the care team for missed dose guidance.
  • Warm powder and sterile water to room temperature before mixing; use within 3 hours of reconstitution.
  • Use new needles/syringes for each dose and dispose of sharps safely.
  • Follow care team directions for disposing of leftover medicine and supplies.