Often used for:
Acute promyelocytic leukemia (APL); also topical for acne
About tretinoin
Tretinoin is a retinoid that acts on nuclear receptors to influence cell growth. As chemotherapy, it is used for APL; topical forms treat acne. Regular lab tests monitor blood counts, lipids, and liver function.
Tretinoin at home
- Oral capsules: take with meals and a full glass of water; swallow whole.
- For feeding tubes, follow specific instructions from the pharmacist.
- Topical forms: apply a thin layer to clean, dry skin at bedtime or as directed.
- Store at room temperature protected from light.
- Give missed doses as soon as possible unless near the next dose; do not double.
Possible side effects
- Dry skin, mouth, nose, or lips
- Rash or itching
- Nausea or vomiting
- Abdominal pain or diarrhea
- Headache
- Changes in blood counts
- APL differentiation syndrome (fever, weight gain, breathing problems, heart issues)
- Mouth sores
- Dry eyes or vision changes
- Sun sensitivity
- Appetite or weight changes
- Fatigue or weakness
- Muscle or joint pain
- Fever, sweating, chills
- Constipation
- Earache
- Hair loss
- Mood changes
- Liver problems
- Increased lipid levels
- Topical forms: skin warmth, stinging, redness, sensitivity, color changes
- Not all patients experience these effects. Report all symptoms.
Tips for families
- Discuss instructions with the care team.
- Avoid vitamin A supplements unless directed.
- Do not take tetracycline or drink alcohol while on tretinoin.
- Protect skin from the sun.
- Use effective birth control during treatment and for 1 month afterward; discontinue immediately if pregnancy occurs.
- Pregnant caregivers should not handle the medicine.
- Follow safe handling and disposal instructions.
