Often used for:
Treatment and prevention of bacterial infections, including Pneumocystis pneumonia
What is sulfamethoxazole-trimethoprim?
Sulfamethoxazole-trimethoprim is a combination antibiotic that kills bacteria and prevents infections in immunocompromised patients. IV administration requires monitoring for extravasation.
Sulfamethoxazole-trimethoprim at home
- Take with or without food; give with food if stomach upset occurs.
- Measure liquid doses with the provided device.
- Give missed doses as soon as possible unless near the next dose; do not double.
- Store at room temperature (follow pharmacy guidance for light protection).
- Complete the entire prescribed course.
Possible side effects
- Nausea or vomiting
- Rash
- Sun sensitivity
- Loss of appetite
- Diarrhea
- Abdominal pain
- Low blood counts
- Allergic reactions (rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in throat, swelling of face or neck)
- Not all patients experience these effects. Report all symptoms.
Tips for patients and families
- Discuss instructions with the care team.
- Take all doses exactly as prescribed; do not skip doses.
- Drink plenty of fluids to prevent kidney problems.
- Avoid alcohol while taking this medicine.
- Protect skin from the sun.
- Patients with a sulfa allergy may not tolerate this medicine; inform the care team before starting.
- Use birth control and inform the care team if pregnant or breastfeeding.
