Often used for:
Lymphoma, leukemia, and solid tumors
What is vorinostat?
Vorinostat is a histone deacetylase inhibitor that slows cancer cell growth. Patients require frequent monitoring of blood counts, blood glucose, and organ function.
Vorinostat at home
- Take at the same time each day with food.
- Swallow capsules whole; do not open or crush.
- Caregivers should wear gloves when handling.
- If a dose is missed and remembered the same day, take it promptly; otherwise skip it.
- Store at room temperature.
Possible side effects
- Fatigue or weakness
- Nausea or vomiting
- Diarrhea
- Changes in taste
- Hair loss
- Chills or fever
- Muscle spasms
- Cold-like symptoms
- Cough
- Swelling of hands, legs, or feet
- Low blood counts
- Constipation
- Loss of appetite and weight loss
- Dry mouth
- Shortness of breath
- Itching
- High blood sugar
- Liver or kidney problems
- Heart problems
- Blood clots
- Fertility problems
- Not all patients experience these effects. Report all symptoms.
Tips for families
- Discuss instructions with the care team.
- Monitor blood sugar, especially in patients with diabetes.
- Drink plenty of fluids as directed.
- Use birth control during treatment and for 6 months afterward.
- Inform the doctor if pregnant or breastfeeding.
- Follow safe handling and disposal procedures for chemotherapy.
